Kadyrkhanova works across drawing, moving image and installation art. As a postgeneration artist, she explores traumatic "inheritance", seeking to touch upon traces and symptoms of trauma and confront narratives that persist in postcolonial and post-totalitarian societies. She has exhibited her works internationally and disseminated her research through publications, artist talks, and conferences. 

She contributed to the edited volume Stalinism in Kazakhstan: History, Memory, Representation (2021). Her hand-drawn animation film All the Dreams We Dream was screened at Documenta 15, Kassel, as part of the DAVRA Collective public programme (2022), and Calvert Journal Film Festival (2021). She was a CEC Artslink fellow at California College of the Arts, USA, in 2018. Other artist residencies and exhibitions include Post-Nomadic Mind, London (2018), Suns and Neons above Kazakhstan, Baku (2017), Internal Memory: Not enough Space?, Moscow, Astana (2017), Protagonists: The Invisible Pavilion of Kazakhstan, Venice (2015).